2/25/2023 0 Comments Immobile muscle growth![]() ![]() 5 Strategies to prevent or treat ICUAW are scarce and mostly focused on the treatment or reduction of risk factors associated with ICUAW (sepsis, hyperglycaemia, catabolism, neuromuscular blockers and corticosteroids). 4, 5 Loss of limb muscle mass is more pronounced in patients with multiple organ failure, 4 while a rapid decline in diaphragm muscle strength and thickness is associated with sepsis 6 and low diaphragm contractile activity. The decline in muscle mass is approximately 2%–4% per day in the first week of ICU stay. 1, 2 ICUAW is a common complication of critical illness with a complex aetiology, 3 affecting both limb muscles as well as respiratory muscles. ![]() Skeletal muscle dysfunction acquired during critical illness (intensive care unit (ICU)-acquired weakness, ICUAW) plays a pivotal role in clinical outcomes such as liberation from mechanical ventilation, ICU length of stay, hospital length of stay, physical function and mortality. ![]()
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